69 The Experimental Methodology and Comparators Used For In Vivo Hernia Mesh Testing; A Ten-Year Scoping Review:

Abstract Aim Before being marketed, hernia mesh must undergo in vivo testing, which often includes biomechanical and histological assessment. Currently there are no universal standards for this testing methods vary greatly within the literature. A scoping review of relevant studies was undertaken to analyse methodologies used testing. Method Medline Embase databases were searched studies. 513 articles identified, 231 duplicates excluded. 126 papers included after abstract full text review. Data extraction using standardized forms. Results Mesh is most commonly tested rats (53%). 78% involve formation a defect; 52% fascia not opposed. The common models use bridge an acute defect (50%). Tensile strength commonest form mechanical (63%). Testing strip widths test speeds (4-30mm 1.625-240mm/minute respectively). There little consensus on units tensile Collagen assessed its abundance (54 studies) more than alignment (18 studies). Alignment measured quantitatively. At least 21 scoring systems Conclusions current practice lacks standardisation. significant inconsistency every category both methodology comparators. We would call upon organisations materials institutions discuss need approach